As tumor-derived TGF-β levels correlate with acetyl-CoA concentrations [56, 396], and given the established link between cellular metabolism and IFN production [157, 397], acetyl-CoA-mediated epigenetic regulation of IFN loci likely contributes to functional differences among tumor-associated DCs subsets (Fig. 4). This evidence concerns the gene TGFB1 and neoplasm.