Although breast and colorectal cancers are among the most common malignancies in the general population, the unusually early age at diagnosis observed in our patients, together with growing evidence on the role of BMPR2 in regulating cell proliferation, inflammatory signaling, and modulation of the tumor microenvironment, suggests a potential association between BMPR2 mutations and the development of epithelial tumors. Here, BMPR2 is linked to neoplasm.