PAX6 and isolated aniridia: For instance, signals in or near albinism related genes (TYR, OCA2), PAX6 (aniridia and other eye development disorders), AHR (recently identified to cause recessive FH with nystagmus),49KIF11 (microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development), COL11A1 (Stickler syndrome), and others suggest that the spectrum from normal to diseased fovea is partly determined by load of common variants in these pathways.