The foveal avascular zone and centrifugal displacement of inner retinal layers are known to be crucial for pit formation,48 and clinical conditions such as retinopathy of prematurity1 and familial exudative vitreoretinopathy,40 including KIF11-related syndromes, provide strong evidence that impaired retinal vascular development leads to FH. The gene discussed is KIF11; the disease is familial hyperaldosteronism.