DICER1 and embryonal rhabdomyosarcoma: The median age at diagnosis for uterine/cervical ERMS is 30 years (range: 2.5–69 years).52 Uterine ERMS and adenosarcoma can be very challenging to distinguish, as only 53% of DICER1 mutant uterine ERMS harbor the characteristic heterologous cartilage foci.52 In turn, adenosarcoma may exhibit rhabdomyoblastic differentiation or sarcomatous overgrowth.53, -55 Thus, DICER1 genetic testing has been proposed as a useful tool in distinguishing between ERMS and adenosarcoma.