2nd degree relative; BMI, body mass index; HDL, high‐density lipoprotein; insulin sensitivity index was measured by euglycemic hyperinsulinemic clamp (M‐value normalized to insulinemia); HOMA‐IR, homeostatic model assessment of insulin resistance; oGTT, 2 h oral glucose tolerance test; T2DM, type 2 diabetes mellitus. The gene discussed is INS; the disease is Insulin resistance.