The ultimate outcomes of the Wnt signaling are demonstrated to be genes with the activity controlled by β‐Catenin and T‐cell factor (TCF).[27] In a study of human colorectal cancer, β‐Catenin interacted with TCF to regulate MMP7 expression.[28] Accordingly, these results further support MMP7 as a direct downstream effector of the Wnt/β‐Catenin signaling pathway that regulates the mechanotransduction in the fibroblasts in response to the mechanical strength of HADA/HRR hydrogels. Here, HNF4A is linked to colorectal cancer.