A recent study on bladder cancer (BC) identified a cancer‐associated PDGFRa+/ITGA11+ fibroblasts subset that created aligned ECM to assist BC cell lymphovascular invasion.[33] Validation via in vitro investigation indicated that fibroblasts tended to migrate toward the HADA/HRR hydrogel with lower mechanical strength, undergoing negative durotaxis. Here, PDGFRA is linked to cancer.