JUN and cancer: Moreover, Schwann cells promote cancer cell invasion in a c‐Jun dependent manner.[22] The expression of ITGB1 increases in Schwann cells in the sciatic nerve after crush and plays an important role in axon‐Schwann cell interaction and axonal regeneration.[56] Consistent with these findings, we revealed that the GC‐ITGB1 axis promotes the dedifferentiation of Schwann cells and facilitates mutual chemoattractant signaling between cancer cells and Schwann cells by upregulating the expression of c‐Jun.