Studies have found that interfering with CXCR4 expression or blocking the CXCR4‐CXCL12 axis using small interfering RNA (siRNA) or other inhibitors (i.e., Plerixafor, TN14003, AMD3100) significantly reduces cell viability, invasion, migration, and adhesion of cancer cells in vitro [83, 84, 85, 86, 87]. The gene discussed is CXCL12; the disease is cancer.