NTRK1 and cancer: Integrins are transmembraneproteins crucial in the regulation of cellular behavior via theirinteraction with the extracellular matrix (ECM).−, ,  Upregulation of the epithelial-specificintegrin αvβ6 has been associated with worse overall survivalrates in several malignancies.−,  This is due to the role of αvβ6in promoting cancer cell migration, invasion, and carcinogenesis,processes that are partially reliant on receptor tyrosine kinase (RTK)activation.