Based on previous reports, boron influences the proliferation, apoptosis, and immune function of lymphocytes via the ERK1/2 signaling pathway.[30] In particular, 0.3 mmol L−1 (3.2 mg L−1) of borate ions promotes the proliferation of human cervical carcinoma cells by activating the ERK1/2 pathway, whereas 5 mmol L−1 (54 mg L−1) of borate ions suppresses such proliferation.[31] Similarly, in the present study, the activation of the ERK1/2 pathway was significantly deteriorated by 3 and 10 mg L−1 of borate ions. This evidence concerns the gene MAPK3 and cervical carcinoma.