2020). Research on the role of HSD17B12 in neurological disorders is limited, with targeted drug development primarily focused on cancer treatment. Our findings revealed that HSD17B12 prevented the onset of IS and exhibited a prophylactic effect against hypertension and essential hypertension. Therefore, further investigation into the role of HSD17B12 in the context of IS required. This evidence concerns the gene HSD17B12 and hypertensive disorder.