2020). In neurological disorders, NEK3 has been implicated in the regulation of neuronal development, neuronal morphology, and polarity (Chang et al. 2009). These findings are consistent with our results, which show that NEK3 was causally associated with the risk of IS. Currently, there is limited research on drug discovery targeting NEK3. Our study provides a direction for future drug development targeting NEK3. Here, NEK3 is linked to nervous system disorder.