The search strategy incorporated both Medical Subject Headings (MeSH) and free-text terms related to “Carperitide” and “heart failure.” Keywords included but were not limited to: “Carperitide,” “atrial natriuretic peptide,” “ANP,” “heart failure,” “cardiac failure,” “acute decompensated heart failure,” “cardiovascular mortality,” “hospitalization,” and “all-cause mortality.” Boolean operators (AND, OR) were used to combine terms appropriately. The gene discussed is NPPA; the disease is heart failure.