It additionally allows for the parameters of heart failure and AD to be monitored simultaneously. However, the collaboration also includes challenges whereby the cardiology records of ejection fraction across the entire period of time were not always accessible, which limits the longitudinal evaluation of cardiac function. Long-term cardiac health should also be routinely monitored using parameters such as left ejection fraction (LVEF) and biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP). This evidence concerns the gene NPPB and Alzheimer disease.