Metastasis is a primary cause of the majority of cancermorbidities and mortalities, and the development of effective treatment programs requires a better understanding of the molecular mechanisms behind this process.7 CALU has been suggested to promote metastasis of cancer cells by interacting with extracellular matrix (ECM) components, such as fibronectin and laminin.8 CALU also has emerged as a regulator of epithelial to mesenchymal transition (EMT), promoting the transition from an epithelial to a mesenchymal phenotype. Here, CALU is linked to cancer.