CALU and cancer: Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth, evasion of apoptosis, invasion of surrounding tissues, and metastasis to distant organs.3 It is imperative to comprehend the molecular mechanisms that propel cancer progression to design potent and efficacious treatment.4 Emerging evidence in recent years suggests that CALU may play a significant role in cancer promotion, and its association with more malignant phenotypes and shorter survival rates for patients has been widely reported.5,6