CALU and neoplasm: This Ca-binding protein enhances the expression of EMT-inducing transcription factors, such as Snail, Twist, and ZEB1, while downregulating epithelial markers like E-cadherin and promoting cancer cell migration, invasion, and resistance to therapy.5,6 Furthermore, CALU may inhibit angiogenesis, a critical process for tumor growth and metastasis through fibulin-1.9,10