Moreover, the usage of BENC-511 inhibitor could successfully reduce the tumor growth in mouse xenograft models over a period of three weeks.50 The selective PI3K-α inhibitor, BYL719, also reduced the survival and proliferation of OPM1/2, RPMI 8226, U266, MM1s, NCI-H929 myeloma cell lines, as well as CD138+ primary cells isolated from BM samples of three MM patients. This evidence concerns the gene SDC1 and plasma cell myeloma.