These regulators inhibit the activation of YAP-1, resulting in the suppression of tumor formation.11 According to the reports, upregulated YAP-1 promotes cell viability when major driver genes are silenced (Figure 1).12 YAP-1 is closely linked to EGFR signaling and is frequently overexpressed in cancer cells resistant to EGFR inhibitors. The gene discussed is EGFR; the disease is cancer.