HIF1A and non-small cell lung carcinoma: Further, EGCG, a potent antioxidant from green tea, could counteract OSI resistance in NSCLC by disrupting the ROS/HIF-1α/YAP-1 axis, thereby reducing oxidative stress, inhibiting HIF-1α stabilization, and suppressing YAP-1 activity to restore EGFR-TKI sensitivity.