TLR4 and chronic myelogenous leukemia, BCR-ABL1 positive: Thus, in a study carried out with a culture of K562 CML cells, it was shown that stimulation by lipopolysaccharide (LPS) mainly increased the expression of sirtuin 1 (SIRT 1), which led to a decrease in the expression of TLR4 based on a reduction in the production of pro‐inflammatory cytokines.