TLR4 and myelodysplastic syndrome: [41] showed that this protein is highly expressed in low‐risk MDS, and the expression of TLR4, also induced by S100A4, showed an attenuation of the cellular senescence process, revealing a probable reduction in the apoptosis rate of neoplastic cells, exhibited in Table 1, whose expression of TLR4, induced by the S100A9 protein, reduces the process of cellular senescence, decreasing the rate of apoptosis of neoplastic cells, also contributing to the progression of the disease [41].