In CML, the high expression of pro‐inflammatory mediators such as TNF, interferon (IFN), IL1‐R has been indicated, as well as the signaling of Toll‐like receptors (TLR) in relation to the actions of TP53 and the processes of cell cycle and apoptosis. The gene discussed is TNF; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.