TFEB and cardiomyopathy: Because dysregulated proteostasis is a major pathological feature of bag3 cardiomyopathy, and dysregulation of autophagy, a dynamic process involving both the formation and clearance of autophagosomes, often contributes to proteostasis disruption (McLendon and Robbins 2015), we evaluated autophagy in bag3e2/e2 mutant fish hearts with or without the Tg(cmlc2:tfeb) transgene.