We found that only the sgRNA targeting the first exon of the fabp7a gene (fabp7aMJ‐e1), but not the other 3 lipodystrophy genes such as bscl2l, cidec, or edn1, restored the cardiac dysfunction in the bag3 cardiomyopathy model at 6 months of age (Figure 3G). The gene discussed is EDN1; the disease is lipodystrophy.