In this study, we further reported that cardiomyocyte‐specific overexpression of the zebrafish tfeb ortholog, a direct downstream target of the mTOR signaling pathway (Napolitano et al. 2018), ameliorated dilated cardiac structure remodeling, restored the decline in cardiac function and prolonged survival in the bag3 cardiomyopathy model. Here, TFEB is linked to cardiomyopathy.