Synuclein Alpha is a member of the synuclein family, which also includes beta‐synuclein and gamma‐synuclein. It may serve to integrate presynaptic signaling and membrane trafficking. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. The gene discussed is SNCB; the disease is early-onset autosomal dominant Alzheimer disease.