In diabetic patients with hyperglycemia, the methylation status of the CpG site cg13399261 of IL1R1 can be used as an epigenetic marker of chronic inflammation and the development of type 2 diabetes.[39] In acute coronary occlusion and stroke, IL1R1 expression is positively correlated with NK cell abundance. The gene discussed is IL1R1; the disease is Hyperglycemia.