In the T2DM validation dataset (GSE78721), the AUCs of IL1R1, MMP9, CD163, TLR5, IRAK3, and LY96 were 0.724, 0.733, 0.720, 0.744, 0.718, and 0.738, respectively (Fig. 10C). This evidence concerns the gene IL1R1 and type 2 diabetes mellitus.