In the T2DM validation dataset (GSE78721), the AUCs of IL1R1, MMP9, CD163, TLR5, IRAK3, and LY96 were 0.724, 0.733, 0.720, 0.744, 0.718, and 0.738, respectively (Fig. 10C). This evidence concerns the gene IRAK3 and type 2 diabetes mellitus.