IRAK3 and ischemic stroke: Low IRAK3 levels are associated with a high incidence of metabolic syndrome, and weight loss is associated with an increase in IRAK3 levels, which is related to a decrease in systemic inflammation and reduction in the number of metabolic syndrome components.[34] Another study showed that, in patients with acute coronary occlusion and ischemic stroke, IRAK3 decreased with increasing NK cell abundance.