SHANK3 and premenstrual tension: According to Qin et al.[21] β-hydroxybutyric acid, the primary metabolite of the ketogenic diet, functions as an endogenous class I histone deacetylase inhibitor, which can restore the synaptic function of SHANK3-deficient mice by improving the histone acetylation level in prefrontal cortex neurons, thereby providing a potential treatment strategy for patients with PMS.