Numerous studies have shown that the TGF-β signaling pathway plays a key role in tumor development.[35,36] In recent years, the pro-cancer effect of this pathway in OS has also been confirmed by several studies.[37,38] Therefore, we surmised that MEF2C in OS may influence the development of OS by regulating the TGF-β signaling pathway. This evidence concerns the gene TGFB1 and cancer.