One study reported a 4.5% incidence of malignancy among 48 individuals with Weaver syndrome and EZH2 variants.[10] Although formal tumor surveillance protocols have not yet been established for Weaver syndrome, the known association between EZH2 and malignancy suggests that a heightened clinical awareness and consideration of age-appropriate cancer screening may be prudent. This evidence concerns the gene EZH2 and neoplasm.