CCL11 and major depressive disorder: Following eosinophil activation, there is an increase in spontaneous reactive oxygen species (ROS) production, enhanced chemotaxis, and reduced apoptosis.[24] Research suggests that CCL11 could penetrate BBB into the brain and induce ROS in microglia, leading to neuronic cytotoxic effects and multiple neurological diseases, for example, SD, anxiety, and depression.[22,23] The aforementioned studies provided possible explanations for our results.