CRP and Hyponatremia: Most patients have an increased serum lactate dehydrogenase level and hypoproteinemia, followed by hyponatremia, hypokalemia, anemia, hyperbilirubinemia, and an increased serum creatine kinase level.[12] The white blood cell count and fibrinogen degradation product, CRP, and soluble interleukin-2 receptor (sIL2-R) levels were significantly increased in severe cases, with sIL2-R levels of 10,000 U/mL or higher produced by activated lymphocytes.