CELSR2 and coronary artery disorder: Studies have shown that the rs7528419-G allele of the CELSR2 gene provides protection against CHD in men.[54] Additionally, there may be a connection between variation in rs75,28,419, found in the SORT1 locus (specifically liver), and progranulin and lipoprotein-associated phospholipase A(2) metabolism.[54,55]