TNF and posterior cortical atrophy: This is a rare and aggressive subtype, which is often accompanied by immunosuppressive infiltration of M2 macrophages and regulatory T-cells, and the significantly increased expression of programmed cell death ligand 1.[30] Previous basic experimental research demonstrated that the elevated levels of cytokines such as IL-30, IL-6, TNF-α, and IL-17 could activate a range of phlogistic pathways, accelerating epigenetic variation and promoting PCa deterioration.[31–33]