The inference of the IVW method suggested that the progress of PCa was positive correlated with ascended abundance of adenosine deaminase (Beta: 1.7661, 95% CI: 0.2092–3.3229, P = .026), axin-1 (Beta: 1.9185, 95% CI: 0.1548–3.6822, P = .033), CXCL6 (Beta: 1.9681, 95% CI: 0.4207–3.5155, P = .013), Flt3L (Beta: 1.6589, 95% CI: 0.0733–3.2446, P = .040), IL-24 (Beta: 2.2091, 95% CI: 0.4682–3.9500, P = .013), IL-33 (Beta: 1.8438, 95% CI: 0.0815–3.6061, P = .040). This evidence concerns the gene ADA and posterior cortical atrophy.