Furthermore, obesity‐induced inflammation results in the production of pro‐inflammatory cytokines, such as interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), and C‐reactive protein (CRP), which contribute to an inflammatory TME conducive to cancer progression.27 The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.