Subsequent work has demonstrated that mutations linked to gut microbiota dysbiosis play a critical role in regulating immune cell invasion within the TME of endometrial cancer, such as mutations in NLR6 (NLR family, pyrin domain containing 6), which regulates the invasion of immune cells into the TME of endometrial cancer (Tregs, monocytes, eosinophils, follicular helper T cells, and gamma delta T cells). The gene discussed is NLRP6; the disease is endometrial cancer.