Clinical traits that were selected included LVEF (≥ 55% or < 55%), NT-proBNP (< 125 pg/mL or ≥ 125 pg/mL), LVH, eGFR (< 60 mL/min/1.73 m2 or ≥ 60 mL/min/1.73 m2), obesity (BMI ≥ 30), HbA1c (< 6.5% or 6.5–6.9%), and uric acid (< 6 mg/dL or ≥ 6 mg/dL for females, < 7 mg/dL or ≥ 7 mg/dL for males). This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.