DHODH and malaria: Prior studies have established that the MOA of antimalarial compounds is correlated with compound kill rate., Many compounds with fast kill MOAs have been found to inhibit the plasma membrane ATP-dependent transporter PfATP4, including a significant percentage of compounds in the Medicines for Malaria Venture’s (MMV) Malaria Box and Pathogen Box.,, As noted above, we had already ruled out DHODH and bc1 as targets using a candidate approach.