Upon viral infection, pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), surveil the pathogen-associated molecular patterns (PAMPs) and thereby trigger the activation of type 1 interferon (IFN-I) signaling [1,2]. The gene discussed is CGAS; the disease is viral infectious disease.