ISG15 and viral infectious disease: Moreover, we observed that IFNβ-induced the mRNA level of Isg15, Isg54, and Isg56 were enhanced in BMDMs and PMs from Lyz2-Cre;Sec10fl/fl mice compared with Sec10fl/fl mice (S2A Fig), indicating that Sec10 can block the downstream signaling transduction of IFN triggered by the viral infection.