Viral infection assay showed that the deletion of endogenous chIRAP promoted viral proliferation at 24 h (Fig 4D-4F), but did not affect the antiviral effect of chIFNλ3 [41], which suggests that although the expression of chIRAP is regulated by chIFNλ3, it may not be an important antiviral protein in the IFN pathway (Fig 4G-4H). This evidence concerns the gene IFNA1 and viral infectious disease.