CD8A and Zika virus infectious disease: In addition, KLRG1+ CD8+ effector T cells and effector memory T cells (Fig 2C) as well as CD8+ T cells expressing granzyme B, interleukin 2 (IL-2) and IFN-γ (Fig 2D) were more frequently detected in B6 mice following ZIKV infection, indicating the activation of CD8+ T cell response in vivo.