CXCL10 and viral infectious disease: Our study identified three major hallmarks of this process: 1) The recruitment of iMO, which display a high level of viral RNA enrichment and are a major source of antiviral responses across all of the myeloid lineages, notably defined by CXCL10 expression; 2) The appearance of MLC cells, which are highly enriched in viral RNA, display evidence of viral infection, express CD3 and exhibit canonical macrophage features; And 3) The synergistic contribution of endothelial and mesenchymal cells in infection resolution via potentiating antiviral responses and myeloid chemotaxis, respectively.