Notably, when examining the average viral titer (Log PFU/mg of tissue) of persistently infected fLX, the ones from CD4 + cell-depleted animals were about 21-fold higher compared to CD3 + cell-depleted fLX (mean Log10 PFU/mg tissue = 3.264 versus 1.930; S8B Fig), furthering that CD4 + cells have a more consequential impact on driving infection resolution than CD3 + cells. This evidence concerns the gene CD4 and infection.