To experimentally validate the importance of the recruitment of circulating monocytes to drive infection resolution in fLX, we therefore performed systemic depletion of CD3 + , CD4 + , and CD8 + cells through the administration of OKT3, OKT4, or OKT8 depleting antibodies, respectively, via intraperitoneal injection of BLT-L mice both prior to and after infection (Fig 9A). The gene discussed is CD8A; the disease is infection.