While depletion of CD3 + , CD4 + , and CD8 + cells induced persistent infection in some or most of the animals, only CD4 + cell depletion (mean Log PFU/mg tissue = 2.37) resulted in a statistically significant defect in infection resolution compared to all other experimental conditions (isotype, OKT3, and OKT8-treated mice) (Fig 9B). Here, CD8A is linked to infection.