CD4 and infection: We first aimed to characterize the T-cell signatures to SARS-CoV-2 infection resolution, and with that, the features of our viral RNA-enriched, 2 dpi-specific, T-cell/ILC subcluster A. T-cell/ILC responses to infection were mainly limited to this specific viral RNA-associated subcluster (Fig 6A-6D), which segregated very distinctively from other CD3 + T-cell lineages, including canonical CD4+ and CD8 + T-cells (Subcluster 6; Fig 6A-6C).