Despite the observed similarities in virus-induced TRIM28 S824 phosphorylation, the effects of infection on SUMO2/3-modified TRIM28 were markedly different between the viruses: while IAV infection led to a near-total loss of SUMO2/3-modified TRIM28, together with a global increase in total SUMO2/3 conjugates as previously described [17,55], neither PIV2 nor PIV5 infection resulted in any detectable loss of SUMO2/3-modified TRIM28 (Fig 4C, D). The gene discussed is SUMO2; the disease is infection.