Herein, we found a heterozygous missense variant Thr148Met in TNFRSF21, since the Pro146Ala variant might result in HM via the regulation of the apoptosis of myopia-related cells [46], the distance between Thr148Met and Pro146Ala is very close, whether Thr148Met acts on myopia in the same mechanism as Pro146Ala needs further explored. The gene discussed is TNFRSF21; the disease is myopia.