MAPT and behavioral variant of frontotemporal dementia: In addition to diagnostic challenges, geographic and genetic factors likely contribute to the heterogeneity in bvFTD incidence and prevalence.55 bvFTD is frequently associated with pathogenic variants in genes such as C9orf72, GRN, and MAPT, which show varying distributions across different populations.56 These genetic differences may partly explain the variability in bvFTD estimates observed between regions.