GLP1R and Sepsis: Recent studies showed that GLP-1 RAs may modulate immune responses, protecting organs in patients with sepsis.45 The research by Steven et al46 using an endotoxic shock model found that liraglutide could attenuate lipopolysaccharide-induced inflammatory pathways, thereby improving vascular function and reducing oxidative stress.46 Another study in lipopolysaccharide-induced septic rats indicated that GLP-1 analogs maintain cardiac function and enhance survival rates.47 These pleiotropic effects may contribute to the broader clinical benefits observed in our study.