VHL and pancreatic neuroendocrine tumor: Twenty-two patients had spRCC, and 22 patients had VHL-associated tumors, including bilateral RCC (45.5% of patients), unilateral RCC (22.7%), CNS hemangioblastoma (86.4%), retinal hemangioma (59.1%), and pancreatic neuroendocrine tumor (50%) (Table 1).