The results presented in Fig. 6(A-C) revealed that, over expression of both TLR4 and Notch1 in TAA induced HE rats resulted in notable elevation in the brain content of NF-κB by 2.03 folds, TNF-α by 4.89 folds, and IL-6 by 3.70 folds compared to healthy rats. Here, TLR4 is linked to hereditary elliptocytosis.