More idiosyncratic changes were observed in other global regulators, including components of the lyt regulon that influences cell wall biosynthesis, lysR-type regulators that regulate metabolic adaptation during infection (91), but also MarR, which has previously been shown to aid antibiotic resistance in S. aureus and that regulates efflux systems that export antibiotics from the cell to the exterior (92, 93). This evidence concerns the gene KARS1 and infection.