Notably, prostate cancer cells demonstrate additional downregulation of mismatch repair (NES = −1.33), homologous recombination (NES = −1.21), and nucleotide excision repair pathways (NES = −1.12), implicating a more critical role for MEP50 in maintaining genome integrity in this context (Fig. 4B). Here, WDR77 is linked to prostate cancer.