Endogenous hypercortisolism diagnosis was based on the elevated 24 h UFC levels: median (Me) – 3,011 nmol/24 h (1,778–6,700) with maximum 15,820 nmol/24 h; LNSC – 87.2 nmol/L (45.5–175.6) with maximum 687 nmol/L; morning ACTH – 143 pg/mL (104–206); and late-night ACTH – 119.8 pg/mL (91–179). This evidence concerns the gene POMC and adrenal gland hyperfunction.