In CRSwNP, TSLP and IL-33 activate ILC2s, driving the release of T2 cytokines, such as IL-4, IL-5, and IL-13, via activation of NF-κB, STAT5, and GATA binding protein 3 signaling [85, 101, 102]. The gene discussed is TSLP; the disease is chronic rhinosinusitis with nasal polyps.