Eosinophilic inflammation in patients with CRSwNP (as well as those with asthma) is also regulated by T2 cytokines that induce epithelial cells to produce eotaxins, which recruit eosinophils to the airway via chemokine receptor 3 (CXCR3) binding [89]. This evidence concerns the gene CXCR3 and chronic rhinosinusitis with nasal polyps.