IL5 and chronic rhinosinusitis with nasal polyps: In addition, S. aureus virulence factors, such as enterotoxin B, can also indirectly induce TSLP and IL-5 production in ethmoid explants from patients with CRSwNP (but not healthy controls) through increased expression of permeability glycoprotein, an efflux pump associated with cytokine transport [70].