RELA regulates various detrimental effects in pancreatic cancer, such as genetic alteration, metabolic changes, acquisition of cancer stem cell properties, angiogenesis and therapy resistance.[10, 19] To characterize the function of RELA in MT‐PHHs, we transduced a pair of sgRELAs into MT‐PHHs that constitutively expressed Cas9‐luciferase to ablate RELA completely (Figure 2C; Figure S4A, Supporting Information). This evidence concerns the gene RELA and cancer.