TP53, the most frequently defective tumor suppressor in HCC,[3] plays a critical role in cell cycle arrest, apoptosis, and senescence in response to various types of stress,[4] and is identified as a “trunk driver” occurring in early HCC.[5] Interestingly, in more than 90% of aflatoxin‐related HCCs, the mutation pattern of TP53 is characterized as R249S.[6] This predominance of R249S highlights its potential to serve as an early biomarker for hepatocarcinogenesis, underscoring the importance of studying the biological process underlying R249S somatic mutation cases in Chinese cohorts. Here, TP53 is linked to hepatocellular carcinoma.