Previous studies revealed that RELA acts as an oncogene in several cancers, such as lung cancer,[40] breast cancer[41] and pancreatic cancer.[42] Some studies have also confirmed the tumor‐promoting function of RELA in HCC.[43] However, these studies haven't considered RELA's role in combination with other frequent genetic alterations in HCC, such as TP53 and MYC. This evidence concerns the gene RELA and neoplasm.