Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that downregulated DEGs in MT‐PHHs‐sgRELA were mainly associated with the pathways related to TNF signaling, NF‐κB signaling, apoptosis and epithelial formation, while upregulated DEGs were highly enriched in the pathways related to hepatocellular carcinoma, Wnt signaling and TGF‐β signaling (Figure 4B,C). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.