DNA sequencing results confirmed the transduction of TP53R249S (Figure 3F; Figure S5B, Supporting Information) as well as the Cas9‐resulted cleavage of RELA (Figure 3F) in all the transformed HCC tumors, while, interestingly, the exogenous MYC overexpression was only observed in one tumor (1/5) (Figure 3F). Here, MYC is linked to hepatocellular carcinoma.