We transplanted MT‐PHHs transduced with sgRNA targeting each candidate plus Cas9 into NSI mice and found that ablation of NF2 or CSK (Figure S2B, Supporting Information) indeed accelerated HCC growth (Figure 1G), which is consistent with previous studies.[17, 18] Of interest, MT‐PHHs transduced with sgRNA targeting RELA (sgRELA) and DPAGT1 (sgDPAGT1) also expanded more robustly than MT‐PHHs transduced with random sgRNA or Cas9 alone in vivo, suggesting that both RELA and DPAGT1 inhibited tumor growth in this model (Figure 1G). The gene discussed is CSK; the disease is hepatocellular carcinoma.