TNF and neoplasm: Indeed, a disrupted metabolic stabilization, which could be driven by TP53 dysfunction mutations,[44] has been reported to shift hepatic NF‐κB/TNF signaling from a pro‐survival to a pro‐apoptotic pathway, eventually leading to hepatocyte deterioration.[45] Thus, we postulate that RELA's tumor‐suppressive role may not be limited to the TP53R249S mutation alone.