Notably, MT‐PHHs‐sgRELA exhibited higher expression of LEF1, TCF7, WNT9A, DVL1, DVL3, CCND1 and LGR5, compared to control cells (Figure 4A,E), suggesting that the canonical Wnt/β‐catenin signaling pathway was activated[26a] and may drive HCC progression upon RELA ablation. This evidence concerns the gene LGR5 and hepatocellular carcinoma.