Notably, TP53 alteration has also been identified as an early event for HCC progression.[5] To this end, we speculate that the observed phenotypes, such as enhanced cell proliferation and promoted EMT driven by RELA loss in TP53R249S‐overexpressing cells, might be dependent on the specific premalignant context of the cells used in this study. This evidence concerns the gene TP53 and hepatocellular carcinoma.