TP53 is recognized as one of the most frequent alterations in HCC patients,[30] among which, cases with the R249S mutation account for more than 90% of HCC patients that harbor TP53 mutations in developing countries such as China.[6] Thus, the correlation between RELA and TP53R249S defined in this study provides a more specific and precise classification in subclasses of HCC. The gene discussed is RELA; the disease is hepatocellular carcinoma.