NFKB1 and hepatocellular carcinoma: The canonical Wnt signaling pathway is reported to play an important role in stemness and metastasis in HCC.[26, 33] Although NF‐κB and Wnt signaling pathways regulate different gene subsets and influence cellular activities through independent cascades, recent research suggests that these two pathways can also interact through physical mediators and downstream target genes, forming a complex network.