Evidence suggests that prolonged glutamine starvation reactivates mTOR, which suppresses autophagy to sustain the viability of oral cancer cells.[72] Consistent with this report, we demonstrated that Cd‐driven MTA metabolic reprogramming facilitates the malignant progression of BC cells by inducing autophagic flux blockade both in vivo and in vitro. The gene discussed is MTOR; the disease is breast cancer.