KEAP1 and Cognitive impairment: Several studies have reported that Keap1 mediated the regulation of Nrf-2 by SFN, and the Keap1/Nrf-2/ARE signaling pathway was involved in the early brain injury and secondary cognitive impairment following SAH (Liu et al., 2015; Zhao et al., 2016a; Dinkova-Kostova et al., 2017).