To determine whether the upregulation of FOSB and MEOX1 contributed to the expression of 316 AD-upregulated genes, we collected FOSB target genes from the MotifMap dataset11, FOSB overexpression-induced genes (the dataset ID: GSE111827), and MEOX1 knockdown-downregulated genes (GSE133927) from the NIH-NCBI GEO database2. The gene discussed is FOSB; the disease is Alzheimer disease.