IFI27 and Alzheimer disease: Notably, three mitochondrial localized genes— solute carrier family 6 member 2 (SLC6A2), MAF BZIP transcription factor F (MAFF), troponin C1, slow skeletal and cardiac type (TNNC1)—and three mitoCarta genes— haloacid dehalogenase like hydrolase domain containing 3 (HDHD3), fragile histidine triad diadenosine triphosphatase (FHIT), interferon alpha inducible protein 27 (IFI27)—were upregulated across multiple cell types in AD brain10 (Figure 1E and Supplementary Figures 2A–E).