Our research on ER-related transcriptomic changes demonstrated that the ER acts as an immune organelle (Saaoud et al., 2024), sensing various danger associated molecular patterns (DAMPs) and initiating ER stress that triggers angiotensin II (AngII)-accelerated trained immunity and differential susceptibilities of thoracic and abdominal aortas to aortic aneurysms (Lu et al., 2023). Here, AGT is linked to aortic aneurysm.