JUN and Alzheimer disease: Additionally, the 3xTg-AD brain upregulated eight DNA damage response genes, four TFs [early growth response 3 (EGR3), FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), MAFF, and recombination signal binding protein for immunoglobulin kappa J region like (RBPJL)], and two differentiation TFs (Ng et al., 2021), FOSB and mesenchyme homeobox 1 (MEOX1).