Our analysis revealed two Tier 2 genes (NOA1 and ELAC2) for BPH, two Tier 3 genes (TRMU and SFXN5) for prostatitis, and six Tier 3 genes (MRPL24, NDUFS6, PUS1, NBR1, GLOD4, and PCBD2) for PCa. Here, SFXN5 is linked to male reproductive organ cancer.