NFE2L2 and multiple sclerosis: Neuroinflammation, mitochondrial dysfunction and oxidative stress are among the key features of neurodegenerative diseases.37 Therefore, as the regulator of antioxidant and detoxification genes Keap1/NRF2/ARE signaling pathway has a major role in treating neurodegenerative pathologies.102,103 As the first clinical reflection of this, an NRF2 activator, DMF, has been successfully used in multiple sclerosis treatment, which is characterized by demyelination and neuronal loss.