TRPV1 and Jeune syndrome: Wang et al. used an N2a/APP cell model of ATD to investigate in detail the neuroprotective potential of the PcActx peptide from zoantharian Palythoa caribaeorum and its underlying mechanism of action, an antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1).62 The PcActx peptide significantly reduced the expression of BACE1, PSEN1 and PSEN2 and the formation of amyloid-related proteins, as shown by Western blot and RT-PCR analyses.