In vitro assessment of therapeutic efficacy of BDNF loaded exosomes in Parkinson's disease (PD) models showed the inhibition of both apoptosis and ferroptosis. In vivo application of exosomes via the tail vein of mice resulted in NRF2 activation, significant reduction of 6-OHDA-induced lipid peroxidation, and protection of dopaminergic neurons from ferroptosis. Overall results exhibit significant neuroprotective effects and potential of treating PD. Here, BDNF is linked to Parkinson disease.