NRF2 modulators are being researched as potential treatments for disorders caused by OS, inflammation, and impaired antioxidant defense mechanisms.31 These include inflammatory disorders, cancer, and neurodegenerative diseases.32 For example, SARS-CoV-2 infection triggers a cytokine storm that causes severe tissue damage.33 Since the NRF2/NF-κB signaling pathways have been linked to the development of inflammation, NRF2 activator may be crucial for the treatment of COVID-19.34 This evidence concerns the gene NFE2L2 and COVID-19.