NFE2L2 and cancer: Targeting NRF2 signaling pathway holds great therapeutic potential since NRF2 is an important transcription factor that can influence and restore cellular redox and protein homeostasis, maintain mitochondrial function, and facilitate antioxidant, anti-inflammatory and detoxification responses.35,36 Therefore, NRF2 modulators could tackle various human diseases such as neurodegenerative disorders,37 autoimmune, metabolic and inflammatory diseases,38 cardiovascular and chronic respiratory, kidney and liver diseases,39,40 and cancer.41